Book An Appointment

Daily injections for Weight Loss in Singapore: Complete Guide (2025)

Introduction

Maintaining a healthy weight has become increasingly challenging in today’s fast-paced environment, especially in urban cities like Singapore where long work hours and sedentary lifestyles are common. As obesity and weight-related medical conditions rise, weight loss injections have offered treatment options beyond the usual dieting and exercise.

One of the most widely used medical weight loss treatments today is Liraglutide (Saxenda®). Approved by the US Food and Drug Administration (FDA), Liraglutide (Saxenda) is a prescription-only injectable medication designed to support sustainable, medically supervised weight loss.

This guide provides a detailed overview of what Liraglutide is, how it works, scientific evidence, expected results, side effects, safety, cost considerations, and whether it may be suitable for you.

What Is Liraglutide (Saxenda)?

Liraglutide (Saxenda) is an FDA approved GLP-1 receptor agonist used specifically for weight management. The active ingredient, mimics a natural hormone known as Glucagon-Like Peptide-1 (GLP-1), which helps regulate appetite, reduce hunger, and promote satiety.

Who Is Liraglutide (Saxenda) Approved For?

In Singapore, Liraglutide (Saxenda) is approved for adults and teenagers (>12 years of age) who meet any of the following criteria:

  • BMI 30 and above, or
  • BMI 27 and above with at least one obesity-related medical condition, such as
  • High blood pressure
  • Type 2 diabetes
  • High cholesterol
  • Sleep apnea
  • Fatty liver disease

Liraglutide (Saxenda) is intended to be used in combination with:

  • A balanced, calorie-controlled diet
  • Regular physical activity
  • Medical supervision and follow-up
Most individuals who adhere to this approach experience 10–15% total body weight loss over 3–6 months.

How Does Liraglutide (Saxenda) Help With Weight Loss?

Liraglutide (Saxenda) works by mimicking the natural GLP-1 hormone released after meals. This hormone plays a crucial role in regulating appetite and food intake. When injected daily, Liraglutide (Saxenda):

1. Reduces Appetite

It sends signals to the brain’s appetite-control center, reducing hunger levels.

2. Slows Gastric Emptying

Food stays in the stomach longer, helping you feel full sooner and for longer periods.

3. Increases Satiety

Patients often report feeling satisfied with smaller portions.

4. Helps Break the Cycle of Overeating

By reducing cravings and emotional eating triggers, Liraglutide (Saxenda) supports healthier eating patterns.

This combination helps reduce calorie intake naturally—without extreme dieting or intense exercise routines.

Clinical Evidence: Does Liraglutide (Saxenda) Really Work?

Landmark SCALE study investigating liraglutide for treatment of obesity

Landmark SCALE study investigating liraglutide for treatment of obesity

One of the most well-known clinical trials evaluating Liraglutide (Saxenda) is the SCALE Obesity and Prediabetes Study, published in the New England Journal of Medicine (NEJM) in 2015. This landmark study provides strong, high-quality evidence supporting the effectiveness and safety of Liraglutide (Saxenda) for weight loss.

Overview of the SCALE Study

  • Duration: 56 weeks
  • Participants: 3,731 adults
  • Average BMI: 38
  • Trial Sites: 191 locations in 27 countries
  • Groups: Saxenda + lifestyle changes vs placebo + lifestyle changes

Participants maintained a healthy diet and regular exercise throughout the study.

Book An Appointment

Key Results After 56 Weeks

Average Weight Loss

  • Liraglutide (Saxenda) group: 8.4 kg lost
  • Placebo group: 2.8 kg lost

This shows that weight loss with Saxenda was almost three times greater compared to lifestyle changes alone.

Percentage of Patients Achieving Significant Weight Loss

  • 63.2% achieved ≥5% weight loss
  • 33.1% achieved ≥10% weight loss
These numbers are clinically meaningful because weight loss of just 5–10% is known to significantly improve metabolic health.

Improved Health Outcomes

Participants on Liraglutide (Saxenda) showed improvements in:

  • Prediabetes and diabetes risk
  • Blood pressure
  • Cholesterol levels
  • Waist circumference
  • Inflammatory markers

This demonstrates that Saxenda is not just about losing weight—it also helps improve overall health and reduce long-term risks.

Benefits of Liraglutide (Saxenda) for Weight Loss

1. Clinically Proven and Approved by major health regulatory bodies (eg US FDA)

Unlike many over-the-counter supplements, Liraglutide (Saxenda) safety and effectiveness are backed by rigorous medical research.

It enhances natural appetite regulation

Average weight reduction of 10–15% is achievable for most patients within several months.

Improvement or prevention of:

  • Hypertension
  • Type 2 diabetes
  • High cholesterol
  • Fatty liver
  • Sleep apnea
  • Joint pain and inflammation
Patients typically eat less naturally, without the psychological strain of restrictive dieting.

Liraglutide (Saxenda) comes in a pre-filled pen with adjustable dosing.

Summary of key outcomes of SCALE study- liraglutide vs placebo

What Is the Liraglutide (Saxenda) Treatment Process Like?

A doctor will assess:
  • BMI
  • Medical history
  • Current medications
  • Existing health issues
  • Weight-loss goals

Liraglutide (Saxenda) dosing starts low and increases gradually to reduce side effects. Smaller build patients (eg females) may not require the full 3mg per day treatment dose and can experience significant appetite suppression at 1.8-2.4mg dosages.

Week Dose
1
0.6 mg
2
1.2 mg
3
1.8 mg
4
2.4 mg
5+
3.0 mg (maintenance dose)
Liraglutide (Saxenda) dose titration

Liraglutide (Saxenda) dose titration

Liraglutide (Saxenda) dose titration

Using a small needle on the abdomen, thigh, or upper arm.

Liraglutide (Saxenda) dose titration

Doctors monitor progress, side effects, lifestyle adjustments, and long-term planning.

Liraglutide (Saxenda) dose titration

What Results Can You Expect?

Most patients lose weight steadily over 12–24 weeks.

Typical Weight Loss Pattern

  • First 4 weeks: Appetite reduction, smaller meals
  • 8–12 weeks: Noticeable weight loss (2–5 kg)
  • 3–6 months: 5–15% total body weight loss
  • Beyond 6 months: Continued loss with lifestyle changes

Aesthetic improvements include:

  • Sharper jawline
  • Reduced facial puffiness
  • Slimmer waistline
  • Fewer inflammatory skin issues

Is Liraglutide Safe?

Liraglutide is generally safe when used under medical supervision.

Common Side Effects

Most appear early and improve after the body adjusts:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Heartburn
  • Mild fatigue

Fewer than 5% of patients discontinue treatment due to side effects, according to the SCALE study.

Rare But Serious Side Effects

  • Pancreatitis
  • Gallstones

These are very uncommon but should be discussed with your doctor before starting treatment.

Who Should Not Use Saxenda?

Saxenda may not be suitable for individuals with:

  • History of pancreatitis or gallstones
  • Thyroid cancer syndromes
  • Pregnancy or breastfeeding
  • Known allergy to liraglutide

Your doctor will assess these factors before prescribing.

Liraglutide (Saxenda) vs Semaglutide (Wegovy) vs Tirzepatide (Mounjaro): How Does It Compare?

As medications like semaglutide (Wegovy) (insert link) and tirzepatide (Mounjaro) (insert link) gain popularity, many Singapore patients want to know how Liraglutide (Saxenda) compares.

Liraglutide (Saxenda)

  • Daily injection
  • 5–15% weight loss

Semaglutide (Wegovy)

  • Weekly injection
  • 10–20% weight loss

Tirzepatide (Mounjaro)

  • Weekly injection
  • 15–25% weight loss

Previously, due to global shortages, Semaglutide (Wegovy) and Tirzepatide (Mounjaro) were not available in Singapore and most patients were prescribed Liraglutide (Saxenda). Currently, majority of patients are switching from Liraglutide (Saxenda) to once weekly injections Semaglutide (Wegovy) and Tirzepatide (Mounjaro).

How Much Does Liraglutide (Saxenda) Cost in Singapore?

Costs may vary by clinic, but typical pricing:

  • $400–$500 per box (3 pens)

Estimated monthly cost:
$300-500 per month, depending on dose.

Most patients use Saxenda for 3–6 months to reach a healthy weight, depending on goals.

Cost of Liraglutide (Saxenda) at Bay Medical Clinic is $400 per box (3 pens, 18mg of liraglutide).

As Liraglutide (Saxenda) is significantly cheaper than Semaglutide (Wegovy) and Tirzepatide (Mounjaro), it represents a more affordable option for cost conscious patients.

Is Liraglutide (Saxenda) Right for You?

You may be a good candidate if you:

  • Struggle with appetite control
  • Have tried dieting without long-term success
  • Have BMI ≥27 with medical conditions
  • Prefer medically supervised treatment
  • Are committed to healthy lifestyle changes

If you want personalised advice, a consultation with a trained doctor is essential.

Book An Appointment

Conclusion: Liraglutide (Saxenda) Is a Safe, Effective and Approved Weight Loss Option in Singapore

Liraglutide (Saxenda) has robust scientific backing, long-term safety data, and regulatory approval. For many individuals, it offers a medically reliable way to achieve sustainable weight loss, improve overall health, and reduce risks associated with obesity.

When combined with healthy habits, Liraglutide (Saxenda) can be a powerful tool in your weight-management journey.

Frequently Asked Questions

Treatment duration is recommended for 6-12 months, or until target weight is achieved.

Patients who are pregnant or breastfeeding, patients with a family history of thyroid cancer or personal history of pancreatitis or gallstone disease.
Results will vary according to several factors- the current weight of the patient, lifestyle modifications (diet and exercise) and duration of treatment. A realistic target would be 10-15% of current body weight over a 12 month period.

Most patients notice reduced appetite within 1–2 weeks and visible weight loss by week 4–8. Full effects are seen after 3–6 months of consistent use.

Clinical studies show an average loss of 10–15% of total body weight over 3–6 months. Some individuals lose more when combined with diet and exercise.

Of course! Saxenda works best with a balanced, calorie-controlled diet and regular physical activity. Patients who combine lifestyle changes typically lose 2–3 times more weight.

Studies support Saxenda’s long-term safety up to 2 years. Your doctor will monitor for side effects and ensure it remains suitable for you.

No. All three are GLP-1 medications, but:

  • Saxenda = liraglutide, daily injection

Ozempic/Wegovy = semaglutide, weekly injection
Wegovy generally results in more weight loss but may not be available in all countries.

Saxenda may not be suitable if you have:

  • History of pancreatitis
  • Thyroid cancer syndromes
  • Severe gastrointestinal disorders
  • Pregnancy or breastfeeding

Always discuss with a doctor first.

Saxenda is approved only for:

  • BMI ≥30, or
  • BMI ≥27 with medical conditions (diabetes, high blood pressure, high cholesterol, sleep apnea)

Doctors will assess eligibility based on guidelines.

Yes, but most patients benefit from continuing lifestyle changes. Stopping suddenly may cause appetite to return. Your doctor will guide you on tapering or maintenance strategies.

Yes. Many patients see significant reductions in abdominal fat, waist circumference, and visceral fat—areas linked to metabolic risk.

Most medications are safe, but certain diabetes medications or appetite suppressants may need adjustments. Always inform your doctor of all medicines and supplements.

Not always, but your doctor may check:

  • Blood sugar levels
  • Lipid profile
  • Liver and kidney function
  • Thyroid markers

This helps ensure safe treatment.

No. While Saxenda reduces appetite, exercise is still essential for metabolism, cardiovascular health, and long-term weight maintenance.

Take it as soon as you remember within 12 hours. If it’s been more than 12 hours, skip the missed dose and continue the next day. Do not double-dose.

Common injection sites include:

  • Abdomen
  • Thigh
  • Upper arm
    Rotate sites to reduce irritation.

Depending on your dose:

  • 0.6 mg: 15–17 days
  • 1.2 mg: 10–12 days
  • 1.8 mg: 6–9 days
  • 3.0 mg: 5–6 days

Saxenda does not usually cause hypoglycaemia unless combined with diabetes medications like insulin or sulfonylureas.

Moderate alcohol is usually safe but may worsen nausea or affect weight-loss efforts. Avoid heavy drinking.

Saxenda is not recommended during pregnancy. If planning to conceive, discontinue and consult your doctor. There is no strong evidence it affects fertility.

Saxenda is approved for adolescents aged 12–17 years with obesity

Yes. Saxenda can be stored at room temperature for up to 30 days once in use. Always keep it in a carry-on bag and bring documentation if flying.

Some regain is possible if lifestyle changes are not maintained. Patients who continue healthy eating and activity often keep most of the weight off.

Unlike slimming pills, Saxenda:

  • Works through hormone regulation
  • Has stronger clinical evidence
  • Is safer for long-term use
  • Is approved for obesity treatment

Yes, they target different aspects of weight and fat reduction. Saxenda manages appetite and weight; fat-freezing targets localised fat.

Patients with hypothyroidism may use Saxenda safely. Those with medullary thyroid carcinoma (MTC) or MEN2 syndromes should avoid it.

The recommended maintenance dose is 3 mg daily. Higher doses are not recommended.

Some patients feel more energetic as they lose weight and sleep improves. Saxenda is not a stimulant, so boosts in energy come naturally from weight loss.
No. It does not cause dependence or withdrawal symptoms.

Saxenda should not be used during breastfeeding. A doctor can advise when it is safe to start postpartum.

References

  1. SCALE Obesity and Prediabetes NN8022-1839 Study Group. Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015 Jul 2;373(1):11-22. doi: 10.1056/NEJMoa1411892. PMID: 26132939.
  2. Kelly AS, Auerbach P, Barrientos-Perez M, Gies I, Hale PM, Marcus C, Mastrandrea LD, Prabhu N, Arslanian S; NN8022-4180 Trial Investigators. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med. 2020 May 28;382(22):2117-2128. doi: 10.1056/NEJMoa1916038. Epub 2020 Mar 31. PMID: 32233338.

Contact Us

Book An Appointment Now

Take the first step toward a healthier, more confident you. Our medical team is ready to answer your questions and guide you through safe, personalised weight-loss options. Reach out today to schedule a consultation or speak with our care specialists.