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Tirzepatide (Mounjaro & Zepbound) Injections in Singapore

Tirzepatide Mounjaro Singapore
mounjaro-kwikpens-edited

Tirzepatide Mounjaro Singapore

Introduction

Tirzepatide (Mounjaro & Zepbound) is an injectable medication used for the treatment of type 2 diabetes and obesity. It is administered subcutaneously (under the skin) once a week. Developed by Eli Lilly, Tirzepatide is FDA-approved under the brand name Mounjaro for diabetes and Zepbound for weight loss and treatment of obstructive sleep apnea. In Singapore, Tirzepatide (Mounjaro) received approval in 2023 for treatment of diabetes, obesity and obstructive sleep apnea.

Mounjaro KwikPen for Tirzepatide subcutaneous injection treatment

Mode of action of Tirzepatide (Mounjaro)

How Does Tirzepatide (Mounjaro) Work?

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Tirzepatide is a dual GIP and GLP-1 receptor agonist, meaning it mimics two important gut hormones involved in metabolic regulation:

  • GIP (Gastric Inhibitory Polypeptide)
  • GLP-1 (Glucagon-Like Peptide-1)

After you eat, these hormones:

  • Trigger insulin release
  • Suppress appetite
  • Slow gastric emptying
  • Increase satiety (fullness)

Tirzepatide activates these receptors in the pancreas, gut, brain, and fatty tissues, leading to significant improvements in blood sugar control and weight loss.

Side Effects of Tirzepatide (Mounjaro)

Common side effects include:

  • Nausea and vomiting
  • Diarrhea or constipation
  • Decreased appetite
  • Abdominal discomfort or pain

These effects are usually temporary and reduce as the dose is increased gradually.

Benefits of Tirzepatide (Mounjaro)

  • Helps improve blood sugar control
  • Significant weight reduction (20-25%)

Heart Failure Benefits

Phase III trials show Tirzepatide reduces risks of:

  • Urgent heart failure visits
  • Hospitalisation
  • Increased diuretic use
  • Cardiovascular-related deaths

A 38% risk reduction vs placebo was reported.

Statistical graph showing weight reduction results from the SURPASS 2 trial

SURPASS-2 Trial: Tirzepatide (Mounjaro) versus Semaglutide (Ozempic) for diabetes

SURPASS-2 Trial: Tirzepatide vs Semaglutide (Ozempic)

Summary: Tirzepatide was superior to semaglutide for both diabetic control and weight loss.

Key Results:

  • 1879 patients, 40-week study
  • Tirzepatide (5mg, 10mg, 15mg) vs Semaglutide 1mg
  • Tirzepatide achieved greater HbA1c reductions
  • More weight loss across all dosages
  • Side effect profile similar between both medications

SURMOUNT-1: Tirzepatide for Obesity (Non-Diabetic Patients)

Summary: Tirzepatide produced substantial and sustained weight loss over 72 weeks.

Results:

  • 2539 adults with obesity
  • Once-weekly Tirzepatide (5mg, 10mg, 15mg)
  • Mean weight reduction:
  • 5mg: 15.0%
  • 10mg: 19.5%
  • 15mg: 20.9%
  • Placebo: 3.1%
  • Up to 57% of participants achieved ≥20% body weight reduction
  • Side effects were mostly mild and occurred during dose escalation
Surmount 1 in the context of tirzepatide mounjaro zepbound

SURMOUNT-1: Tirzepatide for Obesity (Non-Diabetic Patients)

How to Use Tirzepatide (Mounjaro) Injections

Tirzepatide (Mounjaro) is injected once weekly under the skin at the:

  • Abdomen
  • Thigh
  • Upper Arm
  • Abdomen
  • Thigh
  • Upper Arm
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Mounjaro KwikPen for Tirzepatide subcutaneous injection treatment

Storage Instructions for Tirzepatide (Mounjaro) Pens

  • Store between 2°C to 8°C in the refrigerator
  • Do not freeze
  • Keep in original packaging
  • If dropped or damaged, do not use
  • Mounjaro can remain unrefrigerated for up to 30 days
  • Keep below 30°C
  • Avoid heat and direct sunlight

How to Inject Mounjaro (Step-by-Step)

  • Remove pen from refrigerator
  • Check the correct medication and dose
  • Ensure medication is:
  • Not frozen
  • Clear to slightly yellow
  • Particle-free
Medical professional holding an injection pen for diabetes or weight loss
  1. Choose site (abdomen or thigh)
  2. Remove grey cap (never reattach)
  3. Place clear base on skin
  4. Unlock by turning ring
  5. Press purple button and hold for up to 10 seconds
    • 1st click = injection started
    • 2nd click = injection completed
  6. Place used pen into a sharps container
Statistical graph showing weight reduction results from the clinical study trial

Injection technique for Tirzepatide (Mounjaro and ZepBound)

Mounjaro KwikPen for Tirzepatide subcutaneous injection treatment

Tirzepatide (Mounjaro) dosage schedule Singapore

Tirzepatide Dosage (Mounjaro & Zepbound)

Weekly dosing schedule:

  • 2.5mg
  • 5mg
  • 7.5mg
  • 10mg
  • 12.5mg
  • 15mg

Start with 2.5mg, increasing every 4 weeks until optimal results or maximum tolerated dose.

Maximum dose: 15mg weekly

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Where to Buy Tirzepatide (Mounjaro & Zepbound) in Singapore?

Tirzepatide (Mounjaro) is prescription-only and must be obtained from a licensed medical clinic after a doctor’s consultation. It is available in Singapore as Mounjaro (Zepbound is not approved yet, it’s the same thing anyway)

Mounjaro KwikPen for Tirzepatide subcutaneous injection treatment

Price of Tirzepatide (Mounjaro) in Singapore

The price of Tirzepatide (Mounjaro)

  • Tirzepatide (Mounjaro) 5mg/week - $700 for a month (1 pen with 4 doses)
  • Tirzepatide (Mounjaro) 10mg/week- $900 for a month (1 pen with 4 doses)
  • Tirzepatide (Mounjaro) 15mg/week- $1100 for a month (1 pen with 4 doses)

Prices are in SGD, GST 9% applies.

Sources

  1. The Straits Times – New diabetes drug hope
  2. HSA Drug Database
  3. Eli Lilly Mounjaro Official Site

Frequently Asked Questions

Tirzepatide is a prescription injectable medication used for the management of type 2 diabetes and obesity. It functions as a dual GIP and GLP-1 receptor agonist, meaning it mimics natural gut hormones to regulate blood sugar levels, slow gastric emptying, and suppress appetite. It is FDA-approved under the brand name Mounjaro for diabetes and Zepbound for weight management.
Yes, Tirzepatide is available in Singapore under the brand name Mounjaro. It received approval in 2023 for the treatment of diabetes, obesity, and obstructive sleep apnea. While Zepbound utilizes the exact same active ingredient (Tirzepatide), it is not currently approved under that specific brand name in Singapore.

The cost of Mounjaro in Singapore starts at $700 per month for the 5mg weekly dose (which includes one pen with four doses). Pricing depends on the prescribed dosage; the 10mg weekly dose is $900 per month, and the 15mg weekly dose is $1100 per month. Prices are in SGD and are subject to the prevailing 9% GST.

Yes, Tirzepatide is a strictly prescription-only medication in Singapore. It cannot be purchased over the counter. A thorough consultation with a licensed medical practitioner is mandatory to evaluate your health history, determine your suitability, and prescribe the appropriate dosage.

Tirzepatide is administered as a subcutaneous injection (just under the skin) once a week. Patients are typically advised to inject it into the abdomen, thigh, or upper arm using a pre-filled pen device. Your doctor will provide step-by-step guidance on safe injection techniques and proper storage.

Common side effects of Tirzepatide include nausea, vomiting, diarrhoea, constipation, decreased appetite, and abdominal discomfort. These gastrointestinal symptoms are generally temporary and tend to subside as your body adjusts to the medication during the gradual dose escalation. Discussing your medical history with a doctor is necessary to understand all potential risks.

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