Tirzepatide (Mounjaro & Zepbound) Injections in Singapore
Tirzepatide Mounjaro Singapore
Introduction
Tirzepatide (Mounjaro & Zepbound) is an injectable medication used for the treatment of type 2 diabetes and obesity. It is administered subcutaneously (under the skin) once a week. Developed by Eli Lilly, Tirzepatide is FDA-approved under the brand name Mounjaro for diabetes and Zepbound for weight loss and treatment of obstructive sleep apnea. In Singapore, Tirzepatide (Mounjaro) received approval in 2023 for treatment of diabetes, obesity and obstructive sleep apnea.
Mode of action of Tirzepatide (Mounjaro)
How Does Tirzepatide (Mounjaro) Work?
Tirzepatide is a dual GIP and GLP-1 receptor agonist, meaning it mimics two important gut hormones involved in metabolic regulation:
- GIP (Gastric Inhibitory Polypeptide)
- GLP-1 (Glucagon-Like Peptide-1)
After you eat, these hormones:
- Trigger insulin release
- Suppress appetite
- Slow gastric emptying
- Increase satiety (fullness)
Tirzepatide activates these receptors in the pancreas, gut, brain, and fatty tissues, leading to significant improvements in blood sugar control and weight loss.
Side Effects of Tirzepatide (Mounjaro)
Common side effects include:
- Nausea and vomiting
- Diarrhea or constipation
- Decreased appetite
- Abdominal discomfort or pain
These effects are usually temporary and reduce as the dose is increased gradually.
Benefits of Tirzepatide (Mounjaro)
- Helps improve blood sugar control
- Significant weight reduction (20-25%)
Heart Failure Benefits
Phase III trials show Tirzepatide reduces risks of:
- Urgent heart failure visits
- Hospitalisation
- Increased diuretic use
- Cardiovascular-related deaths
A 38% risk reduction vs placebo was reported.
SURPASS-2 Trial: Tirzepatide (Mounjaro) versus Semaglutide (Ozempic) for diabetes
SURPASS-2 Trial: Tirzepatide vs Semaglutide (Ozempic)
Summary: Tirzepatide was superior to semaglutide for both diabetic control and weight loss.
Key Results:
- 1879 patients, 40-week study
- Tirzepatide (5mg, 10mg, 15mg) vs Semaglutide 1mg
- Tirzepatide achieved greater HbA1c reductions
- More weight loss across all dosages
- Side effect profile similar between both medications
SURMOUNT-1: Tirzepatide for Obesity (Non-Diabetic Patients)
Summary: Tirzepatide produced substantial and sustained weight loss over 72 weeks.
Results:
- 2539 adults with obesity
- Once-weekly Tirzepatide (5mg, 10mg, 15mg)
- Mean weight reduction:
- 5mg: 15.0%
- 10mg: 19.5%
- 15mg: 20.9%
- Placebo: 3.1%
- Up to 57% of participants achieved ≥20% body weight reduction
- Side effects were mostly mild and occurred during dose escalation
SURMOUNT-1: Tirzepatide for Obesity (Non-Diabetic Patients)
How to Use Tirzepatide (Mounjaro) Injections
Tirzepatide (Mounjaro) is injected once weekly under the skin at the:
- Abdomen
- Thigh
- Upper Arm
- Abdomen
- Thigh
- Upper Arm
Storage Instructions for Tirzepatide (Mounjaro) Pens
- Store between 2°C to 8°C in the refrigerator
- Do not freeze
- Keep in original packaging
- If dropped or damaged, do not use
- Mounjaro can remain unrefrigerated for up to 30 days
- Keep below 30°C
- Avoid heat and direct sunlight
How to Inject Mounjaro (Step-by-Step)
- Remove pen from refrigerator
- Check the correct medication and dose
- Ensure medication is:
- Not frozen
- Clear to slightly yellow
- Particle-free
- Choose site (abdomen or thigh)
- Remove grey cap (never reattach)
- Place clear base on skin
- Unlock by turning ring
- Press purple button and hold for up to 10 seconds
- 1st click = injection started
- 2nd click = injection completed
- Place used pen into a sharps container
Injection technique for Tirzepatide (Mounjaro and ZepBound)
Tirzepatide (Mounjaro) dosage schedule Singapore
Tirzepatide Dosage (Mounjaro & Zepbound)
Weekly dosing schedule:
- 2.5mg
- 5mg
- 7.5mg
- 10mg
- 12.5mg
- 15mg
Start with 2.5mg, increasing every 4 weeks until optimal results or maximum tolerated dose.
Maximum dose: 15mg weekly
Where to Buy Tirzepatide (Mounjaro & Zepbound) in Singapore?
Tirzepatide (Mounjaro) is prescription-only and must be obtained from a licensed medical clinic after a doctor’s consultation. It is available in Singapore as Mounjaro (Zepbound is not approved yet, it’s the same thing anyway)
Price of Tirzepatide (Mounjaro) in Singapore
The price of Tirzepatide (Mounjaro)
- Tirzepatide (Mounjaro) 5mg/week - $700 for a month (1 pen with 4 doses)
- Tirzepatide (Mounjaro) 10mg/week- $900 for a month (1 pen with 4 doses)
- Tirzepatide (Mounjaro) 15mg/week- $1100 for a month (1 pen with 4 doses)
Prices are in SGD, GST 9% applies.
Sources
- The Straits Times – New diabetes drug hope
- HSA Drug Database
- Eli Lilly Mounjaro Official Site
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